Comparison of oxycodone and hydrocodone for the treatment of acute pain associated with fractures: a double-blind, randomized, controlled trial


Background:
Previous studies have demonstrated the efficacy of oxycodone and hydrocodone for the treatment of acute pain. however, to the best of the authors ‘ cognition, no previous reports have compared the efficacies of these normally order agents .

Objectives:
To compare the efficacies of oxycodone and hydrocodone for the treatment of acute pain associated with fractures in emergency department ( ED ) patients.


Methods:
This prospective, double-blind, randomized, controlled trial was conducted at an urban trauma kernel with an annual census of 65,000. eligible participants included ED patients over the age of 12 years with fractures who consented to participate. Subjects were randomized to receive either oxycodone ( 5 milligram orally [ petty officer ] ) with acetaminophen, or hydrocodone ( 5 milligram petty officer ) with acetaminophen. Measurements included demographic data ; pain scores on a verbal numeric rating scale at service line and at 30 and 60 minutes ; full of life signs at service line and at 30 and 60 minutes ; and adverse effects. Ninety-five-percent assurance intervals ( 95 % CIs ) constructed about means and proportions were used to assess differences between the oxycodone and hydrocodone groups in analgesic efficacy and side effects.

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Results:
seventy-three subjects were randomized to receive oxycodone or hydrocodone. sixty-seven subjects completed the ED analyze period ( north = 35, oxycodone ; n = 32, hydrocodone ). There was no dispute between the two groups in age, weight unit, sex, ethnicity, diagnoses, service line trouble scores, or vital signs. Patients in both groups had pain relief from service line to 30 minutes ( oxycodone entail change 3.7, 95 % CI = 2.9 to 4.6 ; hydrocodone mean deepen 2.5, 95 % CI = 1.7 to 3.3 ), and from baseline to 60 minutes ( oxycodone average change 4.4, 95 % CI = 3.2 to 5.6 ; hydrocodone mean change 3.0, 95 % CI = 2.1 to 3.9 ). There was no remainder in trouble between the patients treated with oxycodone and hydrocodone at 30 minutes ( beggarly remainder between groups -0.6, 95 % CI = -1.8 to 0.5 ) or at 60 minutes ( mean deviation -0.5, 95 % CI = -2.0 to 1.0 ). There was no dispute between the groups in nausea, vomiting, itching, or sleepiness ; however, the hydrocodone patients had a higher incidence of stultification ( oxycodone 0 %, hydrocodone 21 %, difference in proportions 21 %, 95 % CI = 3 % to 39 % more with hydrocodone ).

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Conclusions:
Treatment with acetaminophen and either oxycodone, 5 milligram po, or hydrocodone, 5 magnesium polonium, resulted in pain easing among erectile dysfunction patients with acute fractures, and there was no deviation between the two agents at 30 and 60 minutes. adverse effect profiles were exchangeable, with the exception of a higher incidence of subsequent stultification with the use of hydrocodone. These results suggest that oxycodone and hydrocodone have similarly potent analgesic effects in the foremost hour of treatment for ED patients with acuate fractures .